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KMID : 0811720050090000056
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Korean Journal of Physiology & Pharmacology
2005 Volume.9 No. 0 p.56 ~ p.0
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Role of Prostaglandins on Kainic Acid-induced Seizure Activity Aggravated by NSAID
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Kim Hee-Jae
Kwon Kyoung-Ja
Park Jee-Young
Jung Yi-Sook
Lee Soo-Hwan
Moon Chang-Hyun
Baik Eun-Joo
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Abstract
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It is not well defined whether NSAID aggravates an epileptic seizure, and endogenous prostaglandins affect the seizure activity. The kainic acid(KA)-induced seizure can aggravate by pretreatment of COX-2 inhibitors such as indomethacin and celecoxib (Baik et al., 1999), however it is not known whether the pro-conversant effect of NSAIDs was due to the changes of endogenous prostaglandin. This study was done to determine the effect of prostaglandins administered intra-cisternally on the KA-induced seizure aggravated by indomethacin. Systemic KA injection (10 mg/kg; i.p.) in mice evoked seizure within 15 min. COX inhibitors were pre-treated 1 hr before or post-treated 20 min. after KA injection. Seizures were measured with rating scales. PGD2, PGE2 and PGF2a were administered into the cerebrospinal fluid space. PGF2a, but not PGD2 and PGE2, recovered the KA-induced seizure potentiated by indomethacin. PGF2a also had an anticonvulsant activity on KA-induced seizure without NSAID. All types of COX inhibitors including acetaminophen tend to worsen the seizure activity. Thus, this suggested pre-treated or post-treated all types of COX inhibitors aggravated KA-induced convulsions, which was involved with the changes of endogenous PGF2a. This study was supported by the Korea Science and Engineering Foundation through Chronic Inflammatory Disease Research Center (R13-2003-019).
Source: Korean Journal of Physiology & Pharmacology.2005 Oct;9(Suppl I):S83-S83
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KEYWORD
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Seizure, Prostaglandin, NSAID, Cyclooxygenase
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